Primer on Molecular Genetics
from the U.S. Department of Energy

This primer was prepared by Denise Casey, Human Genome Management Information System, Oak Ridge National Laboratory, for the 1991-92 DOE Human Genome Program Report.

This primer is available in Acrobat (pdf) format. Visit Adobe for free Acrobat Reader software. It is also available in html format from our ftp site.

Begin with the Introduction, or use the table of contents below to skip to a specific section. At the bottom of each page is a forward arrow to proceed to the next page and a back arrow to return to the previous page.

Contents

• Introduction
  • DNA
  • Genes
  • Chromosomes
• Glossary
• Mapping and Sequencing the Human Genome
  • Mapping Strategies
  • Genetic Linkage Maps
  • Physical Maps
    • Low-Resolution Physical Mapping
      • Chromosomal map
      • cDNA map
    • High-Resolution Physical Mapping
      • Macrorestriction maps: Top-down mapping
      • Contig maps: Bottom-up mapping
  • Sequencing Technologies
    • Current Sequencing Technologies
    • Sequencing Technologies Under Development
    • Partial Sequencing to Facilitate Mapping, Gene Identification
  • End Games: Completing Maps and Sequences; Finding Specific Genes
• Model Organism Research
• Informatics: Data Collection and Interpretation
  • Collecting and Storing Data
  • Interpreting Data
  • Mapping Databases
  • Sequence Databases
    • Nucleic Acids (DNA and RNA)
    • Proteins
• Impact of the Human Genome Project

Return to Home Page *or* Return to Research Home Page

Please send questions or comments to caseydk@ornl.gov or bkq@ornl.gov and URL updates or Web questions to martinsa@ornl.gov.

File last modified May 1997